Clinical study of rheumatoid factor (RF) in serum of rheumatoid arthritis (RA)

Comparative Measurement of Rheumatoid Factor in Serum and Synovial Fluid of Rheumatoid Arthritis Patients by ELISA and Latex-Agglutination Test

Rheumatoid factors (RF) are autoantibodies with specificity for the Fc portion of human IgG. Production of RF is a characteristic feature of rheumatoid arthritis (RA) and is detectable in high titer in about 90% of these patients. In this study, we measured total IgM, IgA, IgMRF and IgARF in serum and synovial fluid of 45 RA patients by ELISA and the results were compared with those obtained b...

Study of Oral Gold ( Auranofin ) in Treatment of Iranian Patient with Rheumatoid Arthritis (RA). Preliminary Report of 6 Months Treatment

28 patients with classical / definite RA entered to a prospective open study evaluating efficacy and side effects of Auranofin. 21 patients completed 6 months of therapy with 6 mg Auranofin daily. Parameters of disease activity including Joint Tenderness Score, Joint Swelling Score, Walking Time and duration of Morning Stiffness improved significantly after 6 months (p<0.001). Grip strength, Su...

Control of Rheumatoid Arthritis in Developing Countries

بیماری روماتیسم قلبی یکی از شایعترین علل مرگ و میر ناشی از بیماریهای قلبی و عروقی در کشورهای در حال توسعه می باشد. براساس بررسیهای انجام شده، میزان شیوع بیماری در جامعه و مدارس از ۱ الی ۲۲ در هر هزار نفر کودک می باشد. تخمین زده میشود که تعداد مبتلایان به بیماریهای مزمن روماتیسم قلبی در کشورهای در حال توسعه ۳۰ میلیون و در کشورهای صنعتی ۱ / ۵ میلیون باشد. بسیاری از موارد مرگ و میر ناشی از این بیم...

Differential Expression of Rheumatoid Factor-Associated Cross-Reactive Idiotypes in Iranian Seropositive and Seronegative Patients with Rheumatoid Arthritis

High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) rec...

Catecholestrogens in Rheumatoid Arthritis (RA): Hidden Role